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Simon Joyce (Binghamton)

Feedback Welcome: Structure of Boolean Gene Regulatory Networks

Abstract for the Combinatorics Seminar 2015 December 15

Signed directed graphs are often used as graphical representations of gene regulatory networks. Given a function f: {±1}n → {±1}n, which may arise as representing the ways the activity levels of n mutually interacting genes vary with time, we derive a signed digraph, called the interaction graph of f, intended to model the regulatory network of the genes. I will discuss the structure of these interaction graphs.

Directed cycles in gene regulatory networks are sometimes called feedback loops. Time permitting, I will discuss properties of f that can be inferred from the cycle structure of the interaction graph.

seminars/comb/abstract.201512joy.txt · Last modified: 2020/01/29 14:03 (external edit)