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seminars:stat:200312 [2020/02/28 15:38] – created qyuseminars:stat:200312 [2020/02/28 15:40] (current) – qyu
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 +<WRAP centeralign>##Statistics Seminar##\\ Department of Mathematical Sciences</WRAP>
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 +<WRAP 70% center>
 +^  **DATE:**|Thursday, March 12, 2020 |
 +^  **TIME:**|1:15pm -- 2:15pm |
 +^  **LOCATION:**|WH 100E |
 +^  **SPEAKER:**|Yifei Zeng, Binghamton  University |
 +^  **TITLE:**|Genome-wide mapping of global-to-local genetic effects on human facial shape |
 +</WRAP>
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 +<WRAP centeralign>**Abstract**</WRAP>
 +Genome-wide association scans of complex multipartite traits like the human face typically use preselected phenotypic mea-
 +sures. In this paper, they report a data-driven approach to phenotyping facial shape at multiple levels of organization, allowing for an open-ended description of facial variation while preserving statistical power. Compared to previous study there are 15 replicated loci been detected which highlighted distinctive patterns of global-to-local genetic effects on facial shape and showed
 +enrichment for active chromatin elements in human cranial neural crest cells, suggesting an early developmental origin of the
 +facial variation captured.
 +</WRAP>
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